Pixies - Here Comes Your Man
I nominate Pixies for Best American Band and selected this strange 1989 clip because we see youthful Pixies already making a hot mess, and also because there's a bridge, slight though it may be, to Drew Baird's selection of the Beach Boys. I'd think a Mash-up of Here Comes My Man and God Only Knows could work quite nicely. And, as with The Beach Boys, sonically Pixies influenced waves of bands that followed in their rich, reverby, dark-light/stop-start/quiet-loud wake. Pixies, I say.